Martin Reck Selected Research

Erlotinib Hydrochloride (CP 358,774)

1/2023	RELAY, Ramucirumab Plus Erlotinib (RAM+ERL) in Untreated Metastatic EGFR-Mutant NSCLC (EGFR+ NSCLC): Association Between TP53 Status and Clinical Outcome.
1/2022	RELAY, Ramucirumab Plus Erlotinib Versus Placebo Plus Erlotinib in Patients with Untreated, Epidermal Growth Factor Receptor Mutation-Positive, Metastatic Non-Small-Cell Lung Cancer: Safety Profile and Manageability.
1/2022	RELAY, ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small cell lung cancer: exposure-response relationship.
10/2021	RELAY Subgroup Analyses by EGFR Ex19del and Ex21L858R Mutations for Ramucirumab Plus Erlotinib in Metastatic Non-Small Cell Lung Cancer.
12/2020	Ramucirumab or placebo plus erlotinib in EGFR-mutated, metastatic non-small-cell lung cancer: East Asian subset of RELAY.
10/2020	Patient-reported outcomes in RELAY, a phase 3 trial of ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small-cell lung cancer.
12/2019	Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.
1/2018	Randomized, Double-Blind Phase Ib/III Study of Erlotinib With Ramucirumab or Placebo in Previously Untreated EGFR-Mutant Metastatic Non-Small-Cell Lung Cancer (RELAY): Phase Ib Results.
1/2017	Treatment Rationale and Study Design for the RELAY Study: A Multicenter, Randomized, Double-Blind Study of Erlotinib With Ramucirumab or Placebo in Patients With Epidermal Growth Factor Receptor Mutation-Positive Metastatic Non-Small-Cell Lung Cancer.
4/2016	Examining Treatment Outcomes with Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Whose Tumors Harbor Uncommon EGFR Mutations.

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Martin Reck Research Topics

Disease

209	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2024 - 03/2005
118	Neoplasms (Cancer) 06/2024 - 10/2003
58	Disease Progression 01/2024 - 10/2005
49	Lung Neoplasms (Lung Cancer) 01/2024 - 08/2006
25	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/2024 - 01/2003
18	Adenocarcinoma 01/2023 - 10/2007
17	Neutropenia 01/2021 - 03/2007
12	Brain Neoplasms (Brain Tumor) 12/2023 - 10/2012
12	Neoplasm Metastasis (Metastasis) 12/2023 - 06/2012
11	Exanthema (Rash) 01/2022 - 11/2008
9	Febrile Neutropenia 01/2020 - 03/2007
7	Adenocarcinoma of Lung 07/2023 - 01/2016
6	Fatigue 10/2020 - 03/2012
6	Malignant Mesothelioma 01/2019 - 04/2005
6	Diarrhea 11/2016 - 05/2006
6	Thrombocytopenia (Thrombopenia) 06/2016 - 09/2006
5	Pain (Aches) 10/2020 - 08/2006
5	Melanoma (Melanoma, Malignant) 05/2019 - 06/2012
5	Anemia 12/2014 - 03/2007
4	Cough 10/2020 - 08/2006
4	Hypertension (High Blood Pressure) 01/2020 - 08/2014
3	Body Weight (Weight, Body) 12/2018 - 07/2015
3	Nausea 01/2018 - 11/2011
3	Mesothelioma 01/2017 - 04/2005
3	Sepsis (Septicemia) 02/2014 - 03/2010
2	COVID-19 01/2022 - 01/2020
2	Asthenia 01/2021 - 06/2012
2	Carcinogenesis 01/2021 - 01/2009
2	Dyspnea (Shortness of Breath) 10/2020 - 08/2006
2	Dermatitis 12/2019 - 06/2012
2	Pneumonia (Pneumonitis) 12/2019 - 02/2014
2	Ovarian Neoplasms (Ovarian Cancer) 10/2019 - 05/2015
2	Circulating Neoplastic Cells 06/2019 - 12/2013
2	Fibrosis (Cirrhosis) 01/2019 - 01/2018
2	Renal Cell Carcinoma (Grawitz Tumor) 11/2018 - 04/2016
2	Edema (Dropsy) 01/2018 - 01/2014
2	Vision Disorders (Hemeralopia) 01/2018 - 01/2014
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 05/2015

Drug/Important Bio-Agent (IBA)

49	PlatinumIBA 01/2024 - 01/2003
37	Carboplatin (JM8)FDA LinkGeneric 02/2024 - 08/2003
34	Docetaxel (Taxotere)FDA Link 01/2024 - 01/2008
33	Pemetrexed (MTA)FDA Link 02/2024 - 04/2005
30	Immune Checkpoint InhibitorsIBA 06/2024 - 01/2015
30	ErbB Receptors (EGF Receptor)IBA 12/2023 - 03/2005
28	Biomarkers (Surrogate Marker)IBA 12/2023 - 02/2010
26	B7-H1 AntigenIBA 01/2024 - 11/2016
26	Cisplatin (Platino)FDA LinkGeneric 11/2023 - 04/2005
26	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2023 - 02/2006
24	pembrolizumabIBA 01/2024 - 04/2016
23	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2003
22	RamucirumabIBA 01/2023 - 08/2014
21	NivolumabIBA 02/2024 - 07/2015
21	Bevacizumab (Avastin)FDA Link 01/2022 - 03/2009
20	atezolizumabIBA 02/2024 - 08/2017
20	Tyrosine Kinase InhibitorsIBA 12/2023 - 03/2005
19	nintedanibIBA 01/2023 - 06/2010
18	IpilimumabIBA 02/2024 - 06/2012
15	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2009
13	Etoposide (VP 16)FDA LinkGeneric 02/2024 - 01/2003
13	durvalumabIBA 01/2024 - 04/2016
12	LigandsIBA 12/2023 - 05/2014
12	Gefitinib (Iressa)FDA Link 01/2017 - 03/2005
11	Monoclonal AntibodiesIBA 01/2018 - 03/2009
10	Gemcitabine FDA Link 06/2016 - 09/2006
8	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 12/2008
7	Proteins (Proteins, Gene)FDA Link 06/2023 - 12/2008
5	RNA (Ribonucleic Acid)IBA 11/2023 - 09/2015
4	AntigensIBA 06/2024 - 05/2018
4	cyclopropapyrroloindoleIBA 07/2023 - 01/2019
4	Anaplastic Lymphoma KinaseIBA 11/2021 - 11/2016
4	CrizotinibIBA 11/2021 - 01/2014
4	AntibodiesIBA 07/2019 - 09/2014
4	necitumumabIBA 06/2016 - 03/2015
3	Immunoglobulins (Immunoglobulin)IBA 01/2024 - 10/2017
3	avelumabIBA 09/2023 - 05/2018
3	130-nm albumin-bound paclitaxelIBA 01/2023 - 01/2020
3	Circulating Tumor DNAIBA 01/2023 - 01/2018
3	AfatinibIBA 01/2023 - 03/2014
3	Cell-Free Nucleic AcidsIBA 12/2022 - 01/2018
3	Phosphotransferases (Kinase)IBA 12/2021 - 01/2017
3	Immunoglobulin G (IgG)IBA 01/2020 - 01/2016
3	Angiogenesis InhibitorsIBA 01/2017 - 03/2015
3	Vinorelbine (Navelbine)FDA LinkGeneric 10/2015 - 09/2008
3	Sorafenib (BAY 43-9006)FDA Link 01/2012 - 09/2009
2	Immunoconjugates (Immunoconjugate)IBA 06/2024 - 01/2023
2	EpitopesIBA 06/2024 - 01/2019
2	taxaneIBA 07/2023 - 08/2014
2	osimertinibIBA 04/2022 - 01/2017
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 01/2019
2	Blood Proteins (Serum Proteins)IBA 12/2019 - 01/2012
2	SurvivinIBA 11/2019 - 05/2019
2	EnzymesIBA 01/2018 - 01/2014

Therapy/Procedure

104	Drug Therapy (Chemotherapy) 06/2024 - 04/2005
104	Therapeutics 12/2023 - 03/2005
31	Immunotherapy 01/2024 - 01/2015
6	Chemoradiotherapy 10/2023 - 12/2018
5	Radiotherapy 01/2020 - 10/2010
3	Adjuvant Chemotherapy 01/2016 - 10/2015
3	Drug Tapering 01/2011 - 01/2010
2	Palliative Care (Palliative Therapy) 12/2023 - 03/2016